(shout out to: Google Chrome, Mozilla Firefox and Microsoft’s SharePoint Designer)
Gee thanks guys.
We implemented AppLocker to improve our IT security, and you chaps decided to be clever. The typical call to the Help Desk was
“My Google Chrome doesn’t work anymore.”
Well no, we block applications which are installed into the users profile directory. Which is what Google Chrome/Firefox/Sharepoint Designer do.
The fix was to install Google Chrome with an Admin account.